Service and reagents within Alzheimer’s and Parkinson’s disease research including oligomer-specific antibodies, recombinant and uniform labeled amyloid β peptide, α-synucleins and custom peptide and protein production. Visit our website to find out more www.alexotech.com or contact us at firstname.lastname@example.org
Synthetic and recombinant polypeptides
Alexotech is a biotechnology company established in 2005, specialized within the field of amyloid research, with a specific focus on Alzheimer’s and Parkinson’s disease. We manufacture custom-based peptides including conjugation with most of the commercially available probes such as site-specific phosphorylation, single-site 15N,13C isotope-labeled residues, fluorescent probes, KLH and HRP.
Through a proprietary platform for recombinant production of polypeptides Alexotech manufacture recombinant amyloid β peptides as well as α-synucleins. The recombinant technique generates peptides with a superior homogeneity, as compared to synthetic analogues, which minimizes irregularities and batch to batch variations and is the primary choice where a high-end result is desired.
The recombinant technique facilitates 13C and 15N labeling and Alexotech therefore also offer several products with a uniform isotope labeling. Apart from catalogue products Alexotech provide custom based production of different amyloid β peptides and α-synucleins where isotope-labeling also is an option.
Traditional and oligomer-specific antibodies for amyloid research
The use of antibodies is fundamental within essentially all molecular biology research. Alexotech offer a spectrum of antibodies frequently used within amyloid research. In addition to traditional antibodies, Alexotech has recently launched a selection of monoclonal oligomer-specific antibodies, targeting both amyloid β and α-synuclein, which selectively binds the soluble oligomeric assemblies known to be associated with a high cytotoxic propensity and where these antibodies constitute useful research tools with many interesting applications.
Antigen design and production
Generation of novel antibodies is a continuous process and Alexotech frequently produce peptides and proteins for immunization purposes. Apart from manufacturing all the required material for immunization, including peptides, proteins and conjugation to a carrier protein where applicable, we may also assist with a structure based peptide-design to increase the chances of acquiring antibodies with the desired properties. Alexotech here offer design and production protein antigens including multiple epitope chimeric-proteins which greatly enhance the chances of acquiring the desired antibodies.
Our long experience within the field of protein and peptide research including development of highly sensitive immunological assays, enables a close collaboration with the customer where Alexotech can provide both technical assistance regarding analysis as well as contract-service regarding development of novel reagents and new assays. Our ambition is to fulfil the specific requirements by the customers where we together find the best solution.
Contact us via the web site www.alexotech.com