– Your Expertise in Biotransformation and Metabolites in Safety Testing
MetaSafe AB is a privately owned company located in Biovation Park Telge in Södertälje, Sweden. Metasafe works in state-of-the-art facilities and uses top-of-the-line equipment for the purpose of delivering high quality mass-spectrometric analyses to reveal biotransformation and metabolism characteristics of drugs during all stages of pharmaceutical development.
How? Decades of experience from academia and pharmaceutical industry within the field is utilized and transformed into tactical approaches, tailor made for customer´s purpose. All work is based on high resolution mass spectrometry analyses to investigate metabolism of drugs.
*Photo: Courtesy of Acturum Life Science
This is done through exploratory, problem-solving, and regulatory studies in early phase through metabolic stability and metabolite characterization analysis, reactive metabolite detection, and characterisation. In later phases, e.g. through in vitro cross-species comparisons and metabolite characterization, in pre-clinical and clinical samples generated in different studies performed by our customers. Worth highlighting is also our expertise regarding the “Metabolites in Safety Testing” (MIST) concept, where metabolite exposure comparisons between toxicity species and humans can be made without reference compounds.
Our equipment and licenses also allow for work using radiolabelled compounds/samples.
Through well-designed experiments and studies, data is delivered along the value chain of drug development. We have created and can offer an Analytical Platform of integrated biotransformation work to solve problems and meet both today´s needs and future projectrequirements from authorities.
The platform consists of a battery of experiments and studies with short turnaround times, all without compromising quality. Our innovative way of working transforms minimum efforts into maximum outcome, whereby all experiments and analyses are designed to get the most out of it.
Our Vision is to establish MetaSafe as a resource that small, midsize, and big pharmaceutical companies find attractive to use for effective discussion, design, and execution of regulatory and non-regulatory biotransformation studies, in order to enable progression of their drug projects.
MetaSafe applies high quality and ethical standards. Data handling and archiving procedures allow traceability of data.
Our enthusiastic and flexible mind-set, together with innovative approaches and highly sophisticated instrumentation specifically suitable for studies involving metabolite characterisation, are keys to successful partnership.
MetaSafe lives analysis.