R.E.D. Laboratories – your partner of choice
WHO WE ARE: R.E.D. Laboratories (www.redlabs.com), Belgium-based Company, is developing and performing tests for chronic immune disorders, intestinal dysfunctions and multifactorial affections like autism and chronic fatigue syndrome (CFS).
HOW WE WORK: We are continuously developing new tests according to the specific needs from health care providers. All generated benefits are used for research and development of new assays. We are involved in several international groups aiming to advance knowledge in biological markers of multifactorial affections in general, and autism and CFS in particular.
WHAT WE OFFER: We offer SPECIALTY TESTS. Our tests are research tests. We focus on setting up the tests that are not (or rarely) available elsewhere. Assay development programs at R.E.D. Laboratories focus on disorders that contribute to the onset and pathogenesis of affections such as autism, chronic fatigue syndrome, multiple sclerosis, chronic infections or autoimmune diseases. Specialty tests are grouped in disease or custom-designed Testing Panels.
TESTING OFFER: More and more evidence points towards a combination of factors (genetic, infectious, environmental, etc.) being important in the development of chronic immune dysfunctions. We identified 3 major groups of factors / dysfunctions:
• persistent and/or chronic infections
A majority of patients with immune disorders describe an infectious onset of their disease. Persistent infections and especially chronic zoonoses (like chronic Lyme disease) can contribute to the maintenance of the disease and to the worsening of the symptoms. R.E.D. Labs scientists developed a range of serology and PCR-based assays to support chronic infection testing. In order to offer better management of patients with chronic and/or persistent infections that are very difficult to uncover, we focus both on direct pathogen detection as well as on indirect supportive tests.
• global immune dysfunctions
The extent of the global immune dysfunction is evaluated by testing cytokines’ expression, Th1/Th2 balance, elastase and perforin mRNA expression, macrophage phagocytic activity, alpha-N-acetylgalactosaminidase activity (Nagalase testing), sCD14 expression, CD57 cell subset absolute count, prostaglandine E2 (PGE2) synthesis, genetic polymorphisms and oxidative stress.
• intestinal dysfunctions
We use both blood and stool-based assays to investigate intestinal dysfunctions: IgA/IgM against intestinal bacteria, Lactase deficiency assay, sIgA ELISA tests in stool samples, Inflammation markers in stool samples, MSA assay and PCR-based detection of viral infections.
A frequent disorder of intestinal function is dysbiosis, i.e. the overgrowth of pathogenic bacteria in the intestine.
Alterations in the bowel flora are now believed to be contributing factors to many chronic diseases such as allergies, autoimmune and inflammatory disorders, or degenerative diseases.
Until recently research into microbiota composition relied almost exclusively on culture, while:
• 40 to 80% of gut bacteria cannot be cultured
• Identification of colonies can be difficult
• Bacteria must be alive: studies of anaerobes very difficult, major loss during collection and processing of samples
• Culture approach may address only a small fraction of all bacterial species (10%?)
• E.coli once thought to be a dominant species, is a minor member…
R.E.D. Labs scientists have developed and validated a new procedure to analyze bacterial populations in a stool sample: MSA assay [Frémont et al., Anaerobe 2013]. It’s a new molecular technique involving sequencing of specific regions of bacterial DNA (metagenomics):
• Can be performed on dead organisms (exposure to oxygen, freezing are not a problem)
• Identification of each bacteria by comparing sequence with public databases: extremely precise, not subjective
• High-throughput technology allows identification of tens or even hundreds of thousands organisms in a single sample.
Based on the scientific literature and extensive collaboration with specialized physicians, we developed new testing panels that aim to contribute to a better management of patients with immune disorders:
• Immune dysfunctions panels
• Infections-related panels
• Intestinal dysfunctions panels
• Autism-related biomedical testing panel
• Chronic Fatigue Syndrome biomedical testing panel
WHY TO COLLABORATE WITH US: We aim to develop close interactions with collaborating physicians in order to take the best testing options. We focus on scientific approach.
HOW TO COLLABORATE WITH US: Please download the request form(s) from our website (www.redlabs.com) and send it completed and signed along with the samples to be analyzed. Contact us if you need a specific test that is not (yet) on our request form and we will work together on the new test development.